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  • Title: Progress in methodologies and quality-control strategies in protein cross-linking mass spectrometry.
    Author: Yugandhar K, Zhao Q, Gupta S, Xiong D, Yu H.
    Journal: Proteomics; 2021 Dec; 21(23-24):e2100145. PubMed ID: 34647422.
    Abstract:
    Deciphering the interaction networks and structural dynamics of proteins is pivotal to better understanding their biological functions. Cross-linking mass spectrometry (XL-MS) is a powerful and increasingly popular technology that provides information about protein-protein interactions and their structural constraints for individual proteins and multiprotein complexes on a proteome-scale. In this review, we first assess the coverage and depth of the XL-MS technique by utilizing publicly available datasets. We then delve into the progress in XL-MS experimental and computational methodologies and examine different quality-control strategies reported in the literature. Finally, we discuss the progress in XL-MS applications along with the scope for future improvements.
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