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  • Title: [Leukocyte glycosaminoglycans in various forms of myelo- and lymphoproliferative blood diseases].
    Author: Kharchenko MF, Shatskaia TL, Shcherbakova EG, Abdulkadyrov KM.
    Journal: Vopr Onkol; 1986; 32(10):47-53. PubMed ID: 3465089.
    Abstract:
    The level and composition of glycosaminoglycans (GAG) were studied in leukocytes of healthy donors and patients with different forms of leukemia. GAG level was found to increase in chronic myeloproliferative disorders. This parameter was far below the norm in most cases of acute leukemia. An evaluation of GAG profile established a relationship between cell GAG level variation, the type of proliferating cells and leukemic transformation. Peculiarities of GAG profile in myeloid and lymphoid cells were identified. It was shown that a study of GAG in leukocytes of leukemic patients may contribute to identification of blast elements and differential diagnosis between leukemia types.
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