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  • Title: [Effectiveness and toxicity of high-dosage Ara-C. Clinical observations in 10 cases and review of the literature].
    Author: Morant R, Hofmann V, Honegger HP, Gmür J, Fehr J, Sauter C.
    Journal: Schweiz Med Wochenschr; 1986 Oct 11; 116(41):1415-9. PubMed ID: 3466340.
    Abstract:
    Ten patients with acute myeloid leukemia were treated with a high-dose ara-c regimen (3 g twice daily for 6 days). 5 patients (50%) achieved a complete remission lasting for a median duration of 5 months. These patients had all achieved a complete remission following standard treatment with ara-c. High-dose ara-c was ineffective in 2 patients resistant to standard ara-c protocols. The most important side effects of high-dose ara-c were conjunctivitis and cerebellar symptomatology. In one case a severe diffuse encephalopathy with cerebellar predominance set in at a remarkably late stage (45 days after starting treatment). Our results and those of other authors suggest that treatment with high-dose ara-c should be used with caution.
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