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  • Title: The added value of full and reduced field-of-view apparent diffusion coefficient maps for the evaluation of extramural venous invasion in rectal cancer.
    Author: Zhao L, Liang M, Yang Y, Xie L, Zhang H, Zhao X.
    Journal: Abdom Radiol (NY); 2022 Jan; 47(1):48-55. PubMed ID: 34665287.
    Abstract:
    OBJECTIVE: To investigate the added value of the quantitative analysis of full and reduced field-of-view apparent diffusion coefficient (fADC and rADC) maps for evaluating extramural venous invasion (EMVI) in rectal cancer. MATERIALS AND METHODS: A total of 94 rectal cancer patients who underwent direct surgical resection were enrolled in this prospective study. The EMVI status of each patient was evaluated on T2-weighted imaging. The mean values of fADC and rADC within the whole tumor were obtained, and histogram parameters were also extracted. Multivariate binary logistic regression analysis was used to analyze independent predictors of EMVI and construct combined models. Receiver operating characteristic (ROC) curves were applied to assess the diagnostic performance. RESULTS: The energy, skewness, total energy, and kurtosis of fADC map, and the energy and total energy of rADC map were significantly different between the EMVI-positive and EMVI-negative groups (all P < 0.05). Multivariate logistic regression analysis revealed that kurtosis of fADC and circumferential percentage of tumor were independent predictors of EMVI (odds ratio 1.684 and 2.647, P = 0.020 and 0.009). These two parameters combined with subjective evaluation demonstrated the superior diagnostic performance with the area under the ROC curve, sensitivity, specificity, and accuracy of 0.841 (95% CI 0.752-0.909), 0.739, 0.803, and 0.809, respectively. CONCLUSION: Whole-tumor histogram analysis of ADC map could potentially provide additional information to improve the diagnostic efficiency for assessing EMVI in rectal cancer, which may be beneficial for treatment decision-making.
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