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Title: [Pharmacokinetic studies on cefmenoxime. Distribution into the uterus and intrapelvic genital organs]. Author: Shindo K, Tsuburaya T, Atsumi Y, Sato M. Journal: Jpn J Antibiot; 1986 Sep; 39(9):2386-93. PubMed ID: 3467081. Abstract: Concentrations of cefmenoxime (CMX) in peripheral venous serum, uterus and intrapelvic genital organs were determined by bioassay. The obtained results are summarized below. When 1 g of CMX was administered by an intravenous injection, peak concentrations in various tissues of female genital organs were as follow: 17.4 and 46.8 micrograms/g in ovary and oviduct, respectively, and from 28.2 to 43.8 micrograms/g in other genital organs. These concentrations of CMX were maintained at higher level than minimal inhibitory concentrations against E. coli, Bacteroides and other organisms. In these studies, CMX showed a satisfactory clinical efficacy and a potent antibacteriological effect in the treatment of infections in the field of obstetrics and gynecology.[Abstract] [Full Text] [Related] [New Search]