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  • Title: Maxillonasal dysplasia (Binder's syndrome): a critical review and case study.
    Author: Horswell BB, Holmes AD, Barnett JS, Levant BA.
    Journal: J Oral Maxillofac Surg; 1987 Feb; 45(2):114-22. PubMed ID: 3468213.
    Abstract:
    Binder's syndrome (maxillonasal dysplasia) is a disorder of unknown etiology characterized by nasomaxillary hypoplasia and a 40-50% association of an underdeveloped frontal sinus and cervicospinal abnormalities. The midfacial retrusion is similar to that in chondrodysplasia punctata, resulting in confusion regarding diagnosis. This paper outlines the distinguishing features of Binder's syndrome, the treatment considerations, and presents 24 patients seen and treated. The facial and skeletal characteristics and developmental findings are emphasized to affirm the diagnosis of Binder's syndrome. A familial finding of Binder's features in five patients raises the possibility of a genetic mechanism, a previously undisclosed finding.
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