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  • Title: [The effect of cefotiam in the prophylaxis of postoperative infections in common gynecological surgeries].
    Author: Chimura T, Morisaki N.
    Journal: Jpn J Antibiot; 1986 Oct; 39(10):2721-5. PubMed ID: 3468276.
    Abstract:
    Cefotiam (CTM) was administered to 37 cases of cesarean section and 29 cases of total abdominal hysterectomy for prophylactic purposes. Group I was given the agent at a total dose of 14 g (postoperatively 4, 4, 2, 2 and 2 g), group II at a total dose of 10 g (postoperatively 2, 2, 2, 2 and 2 g) and group III at a total dose of 10 g (2 g during operation and postoperatively 2, 2, 2 and 2 g). When fever indices between the groups were compared, group III showed the lowest level of fever index regardless the type of operation. When the results of laboratory test (WBC, CRP, ESR) between the groups were compared, no significant differences were observed, but group III tended to show lower values than others. No side effects due to CTM were noted. The above results indicate that the administration of CTM during operation was the most effective for protection against postoperative infections in terms of changes in fever index and laboratory test values.
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