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  • Title: [Radioprotective effectiveness and toxicity of 4,5-disubstituted tryptamines].
    Author: Korovkina EP, Chernov GA, Vinograd LKh, Petrunin IA, Suvorov NN.
    Journal: Radiobiologiia; 1986; 26(6):833-6. PubMed ID: 3468557.
    Abstract:
    In experiments on mice a study was made of different substituents in the 4th position of the indole ring of 5-methoxytryptamines (5-MOT) on toxicity and radioprotective efficiency of the compounds of this class. It was shown that the administration of the amino-group to a mexamine molecule increased the preparation toxicity; the nitro-group somewhat diminished the toxic properties, and the acetylamino group did not change 5-MOT toxicity. A 5-MOT derivative with a nitro group possessed the strongest radioprotective action. The radioprotective efficiency of these compounds persisted for 1-2 h.
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