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  • Title: Effect of ion-releasing filler-containing gel application on dentin remineralization using optical coherent tomography.
    Author: Okuwaki T, Sugimura R, Kurokawa H, Tsujimoto A, Takamizawa T, Miyazaki M, Garcia-Godoy F.
    Journal: Am J Dent; 2021 Oct; 34(5):286-292. PubMed ID: 34689454.
    Abstract:
    PURPOSE: To examine the effects of an ion-releasing filler-containing gel on the remineralization of dentin using optical coherence tomography (OCT). METHODS: Dentin slabs of bovine teeth were sliced and shaped into a rectangular form. Specimens were treated with undersaturated 0.1 M lactic acid buffer solution (pH 4.75) for 10 minutes and then placed in artificial saliva (pH 7.0). This procedure was repeated three times a day for 28 days. The dentin remineralization effects of a fluoride/S-PRG filler-containing gel (PRG) and a 38% SDF solution (SDF) on dentin slabs of bovine teeth were compared. After treatment, the dentin slabs were immersed in a 0.1 M lactic acid buffer solution and then placed in artificial saliva. This procedure was repeated three times a day for 28 days. OCT imaging was conducted on the selected location of the dentin surface. The peak intensity and width at 1/e² were recorded in each of the six areas on the sample and averaged. Each group had a sample size of 10. Knoop hardness number (KHN) measurements and scanning electron microscopy (SEM) observations were also conducted. The data for each group were subjected to a one-way repeated-measures ANOVA and Tukey tests (α= 0.05). The samples were also observed using SEM. RESULTS: The peak signal intensities of SDF and PRG decreased on day 7 and then slightly increased during the experimental period for the one-off application groups and then decreased for frequent-time application groups. Although the width at 1/e² in the untreated specimens decreased over the test period, SDF and PRG for the one-off application groups exhibited an increase in widths on day 7 followed by a slight decrease, whereas it increased for the frequent-time application groups. The average KHN of the dentin samples exhibited the same tendency as the width at 1/e². Closure of the dentin tubules and crystal precipitation were detected on the surface of both SDF and PRG groups. CLINICAL SIGNIFICANCE: S-PRG filler-containing gel might have the ability to prevent dentin demineralization and could be useful for the prevention of hard-to-access lesions. This material achieved remineralization of the demineralized root dentin and had the same remineralization ability as SDF in vitro.
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