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  • Title: Rings and double minutes in a case with blastic phase of chronic myelocytic leukemia.
    Author: Uehara M, Kida M, Kamakura M.
    Journal: Cancer Genet Cytogenet; 1987 Apr; 25(2):253-8. PubMed ID: 3470115.
    Abstract:
    The patient studied was a 33-year-old female in the blastic phase of chronic myelocytic leukemia resistant to busulfan. The results of cytogenetic studies of bone marrow cells were as follows: The abnormal chromosomes were double Ph1, +19, +6, +B, ring D, double ring D, double minutes (DM) of various sizes, etc. The mean number of DM per cell was increased in 4-day culture compared with that in 1-day culture.
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