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  • Title: Effects of serotonergic and anticholinergic drugs in haloperidol-induced dystonia in Cebus monkeys.
    Author: Povlsen UJ, Noring U, Laursen AL, Korsgaard S, Gerlach J.
    Journal: Clin Neuropharmacol; 1986; 9(1):84-90. PubMed ID: 3470140.
    Abstract:
    In rodents, serotonin (5-HT) antagonists counteract behavioral and biochemical effects of neuroleptic drugs. Therefore, we have studied the effect of different 5-HT drugs and one anticholinergic drug in acute dystonia in five cebus monkeys chronically treated with haloperidol. Acute dystonia induced by subcutaneous injections of haloperidol was slightly reduced by the 5-HT antagonist methysergide (4.0 mg/kg), while mianserin, ketanserin, and ritanserin (R 55 667; a new selective and potent 5-HT receptor blocker) had no effect. This was contrasted by the marked antidystonic effect of the anticholinergic drug biperiden (0.05-1.0 mg/kg). The 5-HT agonist citalopram, a specific 5-HT uptake inhibitor, had no significant effect. It is concluded that 5-HT antagonists have no useful effect in neuroleptic-induced dystonia.
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