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  • Title: Effect of cis-platinum treatment on 67Ga-citrate localization and elimination in rabbits.
    Author: Sykes TR, Noujaim AA, Stephens-Newsham LG, Lentle BC, Turner AR, Ng PK, Hooper HR.
    Journal: Int J Rad Appl Instrum B; 1986; 13(6):593-7. PubMed ID: 3470273.
    Abstract:
    The treatment of rabbits with a typical dosage schedule of the chemotherapeutic drug cis-platinum resulted in an increased whole body retention of 67Ga-citrate due to decreased urinary and fecal excretion. The biodistribution of the tracer was also affected with most tissues showing greater accumulation. These changes are primarily related to drug-induced renal dysfunction, but other factors may also be involved.
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