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  • Title: Abnormal ocular motor function predicts clinical diagnosis of familial ataxia.
    Author: Hutton JT, Albrecht JW, Kuskowski M, Schut LJ.
    Journal: Neurology; 1987 Apr; 37(4):698-701. PubMed ID: 3470630.
    Abstract:
    Ocular motor performance was significantly impaired in familial ataxia patients as compared with normal controls. Ataxic patients showed prolonged saccadic latencies, longer saccadic refixation times, reduced visual tracking performance, and increased hypermetria. Cutoff values were derived and applied to 15 subjects at risk for developing familial ataxia. Three of 15 showed abnormal values in three or more of four categories of ocular motor performance. Within 3 years, all three subjects were diagnosed on clinical grounds as having familial ataxia. We conclude that ocular motor performance is impaired in familial ataxia and may prove useful for earlier diagnosis.
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