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  • Title: Nesting: hierarchies of allosteric interactions.
    Author: Robert CH, Decker H, Richey B, Gill SJ, Wyman J.
    Journal: Proc Natl Acad Sci U S A; 1987 Apr; 84(7):1891-5. PubMed ID: 3470764.
    Abstract:
    A generalization of the allosteric model is presented that incorporates a hierarchy of conformational equilibria. Such a formulation draws upon structural organization already seen in many large macromolecular systems. The functional binding properties of the macromolecule reflect conformational equilibria at each structural level. Appropriate "nested" models are used to interpret structural features and functional aspects of two hemocyanin systems with a large number (12 and 24) of binding sites.
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