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  • Title: [Pharmacokinetics of the cephalosporin antibiotic cefotiam following its intravenous administration to patients after cholecystectomy].
    Author: Terziivanov D, Gerova Z, Vlakhov V.
    Journal: Vutr Boles; 1986; 25(6):86-91. PubMed ID: 3471005.
    Abstract:
    The pharmacokinetic behaviour of cephalosporin antibiotic, second generation after intravenous administration to patients during the early post-operative period was characterized as well as after cholecystectomy. The data suggest a two-compartment distribution with elimination from the central compartment, realized on account of the renal way of clearance. In one of the patients, with one-compartment distribution of the drug, the presence of the theoretical determining factors in "the collapse" of one two-compartment open model to one-compartment is shown, associated with clinical characteristics of that patient.
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