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  • Title: Macrophages in the central nervous system of the rat.
    Author: Sminia T, de Groot CJ, Dijkstra CD, Koetsier JC, Polman CH.
    Journal: Immunobiology; 1987 Jan; 174(1):43-50. PubMed ID: 3471710.
    Abstract:
    In an immunohistochemical study using monoclonal antibodies, which exclusively recognize cells of the monocyte-macrophage lineage, and monoclonal antibodies against the Ia-antigen, we describe the occurrence of macrophages in the developing and adult central nervous system (CNS). In normal adult brain, no macrophages could be detected in the CNS parenchyma; only in the meninges and the choroid plexes were a few macrophages found. During ontogeny, numerous phagocytic cells infiltrated the CNS parenchyma; these cells which did not express Ia are blood-borne. About three weeks after birth, all macrophages had disappeared from the CNS. As microglia in adult and developing brain do not stain with the anti-macrophage antibodies, we suggest that microglial cells are not related to the mononuclear phagocyte system and do not have a hematogenous origin.
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