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  • Title: Photoredox-Catalyzed Difunctionalization of Unactivated Olefins for Synthesizing Lactam-Substituted gem-Difluoroalkenes.
    Author: Shi J, Guo LY, Hu QP, Liu YT, Li Q, Pan F.
    Journal: Org Lett; 2021 Nov 19; 23(22):8822-8827. PubMed ID: 34723553.
    Abstract:
    Herein, the synthesis of lactam-substituted gem-difluoroalkenes has been developed through a photoredox-catalyzed radical cascade reaction. This developed photoredox-catalyzed, Brønsted base-assisted intramolecular 5-exo-trig cyclization/intermolecular radical addition/β-fluoride elimination reaction offers a simple method for producing lactam, carbamate, or urea-substituted gem-difluoroalkenes with good functional group tolerance and high yields.
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