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  • Title: Radiation Recall Pneumonitis on FDG PET/CT Triggered by COVID-19 Vaccination.
    Author: Hughes NM, Hammer MM, Awad MM, Jacene HA.
    Journal: Clin Nucl Med; 2022 Mar 01; 47(3):e281-e283. PubMed ID: 34739397.
    Abstract:
    A 67-year-old man with metastatic lung adenocarcinoma was initially treated with whole-brain radiotherapy for intracranial metastases, followed by chemotherapy and pembrolizumab. After completing 2 years of systemic therapy, the primary right lung lesion was biopsy-proven to have residual adenocarcinoma, which was then treated with radiation (6000 cGy in 15 fractions). Follow-up serial FDG PET/CT showed radiation fibrosis. Eighteen months after radiotherapy, the patient received 2 doses of an mRNA COVID-19 vaccine. FDG PET/CT performed 4 days following his second vaccine dose showed FDG-avid multistation lymphadenopathy and radiation recall pneumonitis, likely vaccination-induced and mimicking recurrent disease. This resolved spontaneously without therapy.
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