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  • Title: Evaluation of an intraoral controlled release delivery system for fluoride in primates.
    Author: Shern RJ, Mirth DB, Emilson CG, Adderly DD, Bowen WH.
    Journal: Community Dent Oral Epidemiol; 1987 Jun; 15(3):113-6. PubMed ID: 3474094.
    Abstract:
    An intraoral delivery system designed to release 0.5 mg of fluoride per day was evaluated in short-term studies in primates. This fluoride-releasing device, bonded to the buccal surface of the maxillary right central incisor of each of six monkeys (Macaca fascicularis), produced marked elevations in saliva and plaque fluoride concentrations without increases in serum fluoride concentrations. No changes were observed in the plaque and gingival scores or the populations of various species of plaque bacteria.
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