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  • Title: Substitution of phosphatidylserine by lipid A in the activation of purified rabbit brain protein kinase C.
    Author: Ellis CA, Aitken A, Takayama K, Qureshi N.
    Journal: FEBS Lett; 1987 Jun 29; 218(2):238-42. PubMed ID: 3474155.
    Abstract:
    Three lipid A derivatives (hexaacyl monophosphoryl lipid A, hexaacyl diphosphoryl lipid A, and disaccharide precursor IVA) were shown to activate protein kinase C from rabbit brain. These derivatives substituted for phosphatidylserine in a concentration-dependent manner and did not compete for binding of [3H]phorbol dibutyrate to its receptor site. Instead, phorbol dibutyrate binding was increased on raising the concentration of the derivatives in a similar manner to phosphatidylserine. The phorbol ester 12-0-tetra-decanol 13-acetate augmented the activation of protein kinase C by the lipid A derivatives.
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