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  • Title: Identification of Highly Potent α-Glucosidase Inhibitors from Artocarpus integer and Molecular Docking Studies.
    Author: Duong TH, Nguyen HT, Nguyen CH, Tran NM, Danova A, Tran TM, Vu-Huynh KL, Musa V, Jutakanoke R, Nguyen NH, Sichaem J.
    Journal: Chem Biodivers; 2021 Dec; 18(12):e2100499. PubMed ID: 34761862.
    Abstract:
    A new natural Diels-Alder adduct (3) was isolated from the leaves and stem bark of Artocarpus integer, along with seventeen known compounds (1, 2, and 4-18). Structural elucidation was conducted using NMR and HR-ESI-MS data, and comparisons were made with previous studies. Deoxyartonin I (3) exhibited the most potent α-glucosidase inhibition (IC50 7.80±0.1 μM), outperforming the acarbose positive control. This was mixed-mode inhibition, as indicated by the intersect in the second quadrant of each respective plot. An in silico molecular docking model and the pharmacokinetic features of 3 suggest that it is a potential inhibitor of enzyme α-glucosidase, and is therefore a lead candidate as a drug against diabetes mellitus.
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