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  • Title: Catecholamine secretion and adenylate cyclase activation in sea urchin eggs.
    Author: Capasso A, Parisi E, De Prisco P, De Petrocellis B.
    Journal: Cell Biol Int Rep; 1987 Jun; 11(6):457-63. PubMed ID: 3476208.
    Abstract:
    The role of neurotransmitters in sea-urchin eggs was investigated by studying their effect on adenylate cyclase of the egg membrane. Maximal stimulation of enzyme activity occurs in the presence of dopamine and GTP. 5-hydroxytriptamine, 5-methoxytriptamine and acetylcholine have no effect on activity, despite a decrease in intracellular cAMP level in eggs treated with 5-hydroxytriptamine antagonists as previously reported (Renaud et al., 1983). High-performance liquid chromatography (HPLC) revealed that dopamine is released from the sea-urchin egg into the external medium following fertilization.
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