These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Biosynthesis of vitamin B12: concerning the origin of the methine protons of the corrin nucleus.
    Author: Scott AI, Kajiwara M, Santander PJ.
    Journal: Proc Natl Acad Sci U S A; 1987 Oct; 84(19):6616-8. PubMed ID: 3477792.
    Abstract:
    13C NMR spectroscopy has been used to locate six deuterium atoms incorporated biosynthetically on the periphery of the corrin nucleus of vitamin B12 (cyanocobalamin) derived from cells of Propionibacterium shermanii grown in a medium containing 50% 2H2O and 13C-enriched delta-aminolevulinic acid. The implications of these results for the mechanism of vitamin B12 biosynthesis are discussed, and it is concluded that the same oxidation level of the intermediates is maintained throughout the biosynthetic pathway, from delta-aminolevulinic acid to corrin.
    [Abstract] [Full Text] [Related] [New Search]