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  • Title: [Physiological and pathological responses to altitude].
    Author: Doutreleau S.
    Journal: Rev Mal Respir; 2021 Dec; 38(10):1013-1024. PubMed ID: 34782179.
    Abstract:
    Hypobaric hypoxia, the hallmark of a high altitude environment, has important physiological effects on both the cardiovascular and respiratory systems in order to maintain a balance between oxygen demand and supply. This dynamic of acclimatization is influenced both by the level of altitude and the speed of progression, but is also very individual with a wide spectrum of responses and sensitivities. This wide range of responses is associated with nonspecific symptoms characterising acute mountain sickness and high-altitude cerebral or pulmonary oedema. This article reviews the current knowledge about both the acclimatization processes and specific diseases of high-altitude.
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