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  • Title: Arugomycin, a new anthracycline antibiotic. I. Taxonomy, fermentation, isolation and physico-chemical properties.
    Author: Kawai H, Hayakawa Y, Nakagawa M, Furihata K, Furihata K, Shimazu A, Seto H, Otake N.
    Journal: J Antibiot (Tokyo); 1987 Sep; 40(9):1266-72. PubMed ID: 3479412.
    Abstract:
    Arugomycin (AGM) is a new anthracycline antibiotic produced by strain No. 1098-AV2 which was identified as Streptomyces violaceochromogenes. AGM was isolated by solvent extraction, silicic acid chromatography and Sephadex LH-20 column chromatography. Acid treatment of AGM gave the chromophore, named arugorol, which was identified as 4'-epi-nogalarol, and sugar moieties. AGM inhibited the growth of Gram-positive bacteria and showed antitumor activity against sarcoma S-180 and Ehrlich ascites tumors.
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