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  • Title: Collagen phagocytosis by fibroblasts in the periodontal ligament of the mouse molar during the initial phase of hypofunction.
    Author: Beertsen W.
    Journal: J Dent Res; 1987 Dec; 66(12):1708-12. PubMed ID: 3479468.
    Abstract:
    This study was undertaken in order to determine whether hypofunction of teeth is associated with changes in collagen phagocytosis by fibroblasts of the periodontal ligament. In mice, the lower right molars were extracted and the animals killed one, two, three, four, or seven days later. The maxillary first molars with their surrounding periodontium were processed for electron microscopy and their periodontal ligament subjected to morphometric analysis. It was observed that, whereas the volume density of extracellular collagen in the ligament of the hypofunctional molars decreased from 50% to 30% during the course of the experiment, the fraction of fibrillar collagen ingested by the cells increased over two-fold. This increase was already manifest very shortly after the onset of the experiment and offers an explanation for the net loss of collagen fibrils from the extracellular space.
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