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  • Title: [A Case of Neuroendocrine Carcinoma Originating from the Papilla of Vater].
    Author: Nishiyama T, Ogawa M, Nakamoto K, Nakao S, Fukuoka T, Nakagawa Y, Iseki Y, Yamamoto T.
    Journal: Gan To Kagaku Ryoho; 2021 Nov; 48(11):1401-1403. PubMed ID: 34795135.
    Abstract:
    A woman in her late 70s with fatigue, nausea, and epigastric discomfort was found to have a tumor at the papilla of Vater through endoscopy. We performed subtotal stomach-preserving pancreaticoduodenectomy with regional lymph node dissection. The immunohistological analysis showed positive staining for chromogranin A, synaptophysin, and CD56. The definitive diagnosis was neuroendocrine carcinoma of the papilla of Vater. Although the patient declined adjuvant chemotherapy, she had to start chemotherapy with carboplatin and etoposide because multiple liver metastases, lymph node metastasis, and peritoneal dissemination occurred 6 months after surgery. We performed 6 courses of chemotherapy. However, progressive disease(PD)was assessed, and she died of cancer 13 months after the surgery. The prognosis of the disease is poor when surgery alone is performed. Adjuvant chemotherapy, in addition to surgery, may be necessary.
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