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  • Title: Prophylactic effect of lithium and imipramine in unipolar and bipolar II patients: a preliminary report.
    Author: Quitkin F, Rifkin A, Kane J, Ramos-Lorenzi JR, Klein DF.
    Journal: Am J Psychiatry; 1978 May; 135(5):570-2. PubMed ID: 347953.
    Abstract:
    Relapse rates of the first 35 unipolar and bipolar II manic-depressive patients who entered the controlled phase of a continuing evaluation of the prophylactic value of lithium alone or in combination with imipramine were analyzed. Lithium had a prophylactic effect in unipolar patients and possibly in bipolar II patients. Imipramine did not have a prophylactic effect in either group of patients.
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