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  • Title: Inhibitory effect of fumaric acid on hepatocarcinogenesis by thioacetamide in rats.
    Author: Kuroda K, Terao K, Akao M.
    Journal: J Natl Cancer Inst; 1987 Nov; 79(5):1047-51. PubMed ID: 3479633.
    Abstract:
    An inhibitory effect of fumaric acid (FA) on hepatocarcinogenesis was examined in rats fed thioacetamide (TAA). A group of male DONRYU rats were fed TAA at a level of 0.035% in the diet for 40 weeks and then fed a basal diet for 40 weeks. Hepatic carcinomas developed in 9 of 41 animals of this group fed TAA alone. The effect of FA on the carcinogenesis was examined in 2 groups fed both TAA and FA; one group of rats were fed FA at 1% in a basal diet after ingestion of TAA, and another group of rats were fed TAA plus a supplement of 1% FA in the diet. The inhibitory effect of FA on TAA carcinogenesis was so marked that no hepatic carcinomas were found in both groups fed FA in combination with TAA.
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