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  • Title: [Treatment of hyperplastic processes in the endometrium of women of child-bearing age using different types of synthetic progestins].
    Author: Manuilova IA, Sotnikova EI.
    Journal: Akush Ginekol (Mosk); 1978 Mar; (3):39-42. PubMed ID: 347966.
    Abstract:
    It has been proved that a prolonged use of synthetic progestins in patients with hyperplastic processes may provoke an atrophy of the endometrium and anovulation and amenorrhea. The authors studied the effectiveness of an administration of combined and pure gestagens for the treatment of hyperplastic processes of the endometrium. Taking into consideration the ability of estrogen-gestagen preparations to provoke a stimulating action on the hypothalamo-hypophysis-ovarian system and to cause ovulation, the authors studied 105 patients with dysfunctional bleeding. The patients were aged 19 to 42. The duration of the disturbance was over 5 years on the average. All patients were suffering from anovulation. Functional diagnostic tests and the measurement of the steroid hormone level in the urine and the plasma revealed in all patients an estrogen saturation in the organism. Histological studies showed hyperplastic processes with the absence of secretion changes in the endometrium in 85 women. The study of the gonadotropic function of the hypophysis, based on the luteinizing and follicle stimulating hormones, showed a disturbance of the corrective gonadotropin secretion rythm with a disappearance of the peak in the middle of the menstrual cycle. The authors believe that these results are of primary importance for the endocrine aspect of cancerogenesis in the endometrium.
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