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  • Title: Immunohistochemical localization of types I and III collagen and fibronectin in the dentine of carious human teeth.
    Author: Karjalainen S, Söderling E, Pelliniemi L, Foidart JM.
    Journal: Arch Oral Biol; 1986; 31(12):801-6. PubMed ID: 3479953.
    Abstract:
    Reparative dentine formed as a response to caries was mostly type I collagen similar to that of normal dentine. The predentine related to reparative dentine reacted positively with antisera to types I and III collagen and to fibronectin. Normal odontoblasts and their processes reacted positively both with types I and III collagen antibodies. Fibronectin was related to odontoblasts and their processes pericellularly. Odontoblasts appeared not to lose totally their developmental ability to synthesize type III-like molecules after maturation. Pulp fibroblasts reacted positively both with types I and III antibodies as well as antifibronectin. The cell-free and cell-rich zones revealed a dense layer of fibres reacting positively with type III collagen and fibronectin antibodies. The width of these zones were reduced in relation to reparative dentine.
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