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  • Title: Philadelphia-positive chronic myelogenous leukemia with breakpoint 5' of the breakpoint cluster region but within the bcr gene.
    Author: Bartram CR, Bross-Bach U, Schmidt H, Waller HD.
    Journal: Blut; 1987 Dec; 55(6):505-11. PubMed ID: 3480009.
    Abstract:
    We report on the first Philadelphia chromosome (Ph) positive chronic myelogenous leukemia (CML) characterized by a rearrangement within the 5' part of the bcr gene on chromosome 22, but outside the restricted breakpoint cluster region. In situ hybridization studies revealed a translocation of the c-abl oncogene to the Ph chromosome and Northern blot analysis identified a chimeric 8 kb bcr/abl RNA transcript in leukemic cells. These data suggest that 1. less bcr coding sequences than previously assumed may be essential for the putative transforming activity of the rearranged bcr/abl gene and 2. the bcr probes currently used for diagnostic purposes could miss Ph-positive CML cases.
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