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  • Title: Oral pharmacokinetics and ascitic fluid penetration of pefloxacin in cirrhosis.
    Author: Cardey J, Silvain C, Bouquet S, Breux JP, Becq-Giraudon B, Fourtillan JP, Beauchant M.
    Journal: Eur J Clin Pharmacol; 1987; 33(5):469-72. PubMed ID: 3480805.
    Abstract:
    Plasma and ascitic fluid concentrations of pefloxacin in 10 cirrhotic patients and 8 healthy volunteers were determined following administration of a single oral dose of 400 mg. The mean elimination half-life was significantly increased in the patients (29.0 h) compared to in 8 healthy volunteers (12.3 h). In patients, the total plasma clearance (2.71 vs 6.85 l/h) and volume of distribution (1.12 vs 1.67 l/kg) were decreased. Estimated by the ratio of the AUC in peritoneal fluid and plasma, ascitic fluid penetration was 68% after one oral dose, and pronounced accumulation of pefloxacin in ascites was found after repeated doses. Oral pefloxacin would seem to be a convenient and useful treatment of spontaneous, gram-negative, bacterial peritonitis in cirrhosis. However, the decreased hepatic metabolism of the drug leads to a marked accumulation in plasma and ascites after repeated doses, and a reduced dose is required in these patients.
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