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  • Title: Mutagenicity of aclacinomycin A and daunomycin derivatives.
    Author: Umezawa K, Sawamura M, Matsushima T, Sugimura T.
    Journal: Cancer Res; 1978 Jun; 38(6):1782-4. PubMed ID: 348304.
    Abstract:
    An antitumor antibiotic aclacinomycin A, was nonmutagenic in a Salmonella test, but its derivative, N-demethylaclacinomycin A, was mutagenic. Similarly, 1-deoxypyrromycin, a hydrolysis product of aclacinomycin A, was nonmutagenic, but N-demethyl-1-deoxypyrromycin was mutagenic. Daunomycin was highly mutagenic, but N-methyldaunomycin showed only weak mutagenicity, and N-dimethyldaunomycin was nonmutagenic. The aglycones of aclacinomycin A and daunomycin were not mutagenic. Thus, the amino moiety of anthracycline glycosides is concluded to be essential for mutagenesis.
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