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  • Title: [Radioimmunologic determination of the progestagen dienogest in plasma and saliva].
    Author: Hobe G, Klinger G, Reddersen G, Erdmann A, Klinger G.
    Journal: Pharmazie; 1986 Nov; 41(11):772-4. PubMed ID: 3484359.
    Abstract:
    Following oral administration of 2 mg of dienogest (17 alpha-cyanomethyl-17 beta-hydroxy-4,9-estradien-3-one) to female volunteers, the dienogest concentration courses in plasma and saliva were determined by means of a specific radioimmunoassay (RIA). Three different procedures of the plasma sample preparation prior to the RIA were compared. The dienogest RIA was directly applied to saliva. There is a high correlation between the dienogest concentrations in plasma and saliva. The dienogest plasma elimination half life of about 9 hrs is not significantly different from that derived from saliva. The salivary dienogest concentrations indicate a relatively high non-protein bound portion of this steroid drug in plasma. Following repeated oral administration of dienogest (tau = 24 hrs), there is no significant cumulation of plasma dienogest.
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