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  • Title: Complications of intraarterial urokinase-lys-plasminogen infusion therapy in arterial ischemia of lower limbs.
    Author: Fiessinger JN, Vitoux JF, Pernes JM, Roncato M, Aiach M, Gaux JC.
    Journal: AJR Am J Roentgenol; 1986 Jan; 146(1):157-9. PubMed ID: 3484402.
    Abstract:
    Thirty-five patients with peripheral arterial occlusions were treated by intraarterial infusion of low-dose urokinase associated with bolus of lys-plasminogen. Thrombolysis was achieved in 26 cases (74%), but only 10 patients (28.5%) experienced sustained improvement. Complications of thrombolysis occurred in 11 patients: Five patients developed groin hematoma, five had distal emboli, and one experienced macroscopic hematuria. Catheter-related thrombosis was observed in 14 patients (40%) despite intravenous heparin. Nine patients suffered from recurrent thrombosis and three from proximal emboli. A patient died from catheter-related infection. Limited fibrinolysis could increase pericatheter thrombosis, and further work will be necessary to assess the local risk of intraarterial thrombolysis.
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