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  • Title: Specific detection of IMP-1 β-lactamase activity using a trans cephalosporin-based fluorogenic probe.
    Author: Hu L, Liu R, Ma Z, Yu T, Li Z, Zou Y, Yuan C, Chen F, Xie H.
    Journal: Chem Commun (Camb); 2021 Dec 14; 57(99):13586-13589. PubMed ID: 34847209.
    Abstract:
    A fluorogenic probe for the specific detection of IMP-1 β-lactamase activity has been developed. This imaging reagent features a unique trans-acetylamino cephalosporin as an enzymatic recognition moiety, exhibiting excellent selectivity to IMP-1 β-lactamase over other β-lactamases, including serine- and metallo-β-lactamases. The selective activation of the probe by IMP-1 β-lactamase leads to over 30-fold enhancement in the fluorescence intensity, which allows enzyme activity to be reported with high sensitivity.
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