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  • Title: Alverine citrate promotes myogenic differentiation and ameliorates muscle atrophy.
    Author: Yoon JH, Lee SM, Lee Y, Kim MJ, Yang JW, Choi JY, Kwak JY, Lee KP, Yang YR, Kwon KS.
    Journal: Biochem Biophys Res Commun; 2022 Jan 01; 586():157-162. PubMed ID: 34847441.
    Abstract:
    Sarcopenia is the age-related loss of muscle mass and function and no pharmacological medication has been approved for its treatment. We established an atrogin-1/MAFbx promoter assay to find drug candidates that inhibit myotube atrophy. Alverine citrate (AC) was identified using high-throughput screening of an existing drug library. AC is an established medicine for stomach and intestinal spasms. AC treatment increased myotube diameter and inhibited atrophy signals induced by either C26-conditioned medium or dexamethasone in cultured C2C12 myoblasts. AC also enhanced myoblast fusion through the upregulation of fusion-related genes during C2C12 myoblast differentiation. Oral administration of AC improves muscle mass and physical performance in aged mice, as well as hindlimb-disused mice. Taken together, our data suggest that AC may be a novel therapeutic candidate for improving muscle weakness, including sarcopenia.
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