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  • Title: HLA-DR3 antigen linkage in patients with hypertrophic obstructive cardiomyopathy.
    Author: Fiorito S, Autore C, Fragola PV, Purpura M, Cannata D, Sangiorgi M.
    Journal: Am Heart J; 1986 Jan; 111(1):91-4. PubMed ID: 3484891.
    Abstract:
    In order to investigate if genetic factors could be involved in the pathogenesis of hypertrophic obstructive cardiomyopathy, we determined HLA-A, HLA-B, HLA-C, and HLA-DR specificities in 12 Italian patients affected with the disease and in healthy family members of one of them. HLA-DR3 was found in 50% of patients as compared to 17.1% of normal control subjects (p = 0.023, relative risk = 4.82). The two relatives also had HLA-DR3 antigen and, in addition, showed equivocal signs of hypertrophy at echocardiographic examination. Thus hypertrophic obstructive cardiomyopathy is associated with genes in the HLA-DR region, and immunogenetic factors could be involved in the pathogenesis of the disease. Furthermore, the minimal target organ abnormalities in "healthy" relatives could represent a subclinical stage of the disease.
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