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  • Title: Enhanced hydrophilicity and anticoagulation of polysulfone materials modified via dihydroxypropyl, sulfonic groups and chitosan.
    Author: Wang C, Lin B, Qiu Y.
    Journal: Colloids Surf B Biointerfaces; 2022 Feb; 210():112243. PubMed ID: 34861540.
    Abstract:
    A novel modified polysulfone (PSF) is successfully prepared for hemodialysis by grafting with a well-defined heparin-like polymer, sulfonated dihydroxypropyl chitosan (SDHPCS), which is obtained in proper sequence via alkalization of chitosan, etherification and sulfonation. PSF is modified via chloroacetyl chloride, and then, the chloroacylated polysulfone (CAPSF) with pristine PSF is transformed into CAPSF/PSF blend membrane via the phase inversion, followed introducing amino group into CAPSF on the surface and taking glutaraldehyde as bridge between modified PSF membrane and SDHPCS. The result of 1H NMR spectrum of prepared CAPSF indicates that the degree of the substitution of chloroacetyl group. The SEM, EDS mapping, FTIR and XPS show that SDHPCS-g-PSF membranes are successfully prepared. The hydrophilicity of the membrane modified by SDHPCS is improved obviously, and the contact angle remarkably reduced from 87 ° to below 45°, exhibiting much better hydrophilicity. The hemocompatibility characterizations including BSA adsorption, Plasma recalcification time (PRT), hemolysis ratio (HR), activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) also certificates that SDHPCS-g-PSF possesses lower BSA adsorption and enhanced blood compatibility.
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