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  • Title: Cardiovascular effects of positive end-expiratory pressure in dogs.
    Author: Cassidy SS, Robertson CH, Pierce AK, Johnson RL.
    Journal: J Appl Physiol Respir Environ Exerc Physiol; 1978 May; 44(5):743-50. PubMed ID: 348658.
    Abstract:
    Our purpose was to reexamine the relationship of the fall in cardiac output and blood pressure which occurs during positive end-expiratory pressure (PEEP) to changes in transmural right atrial and left atrial filling pressures. Closed-chest dogs, half with pulmonary edema, were studied during spontaneous breathing and inspiratory positive-pressure breathing (IPPB) with 0-15 cmH2O PEEP. Mean esophageal pressure accurately reflected changes in pericardial pressure and was used to estimate extracardiac pressure. We found that cardiac output fell approximately 50% and blood pressure fell 20% during 15 cmH2OPEEP in spite of well maintained transmural right atrial and left atrial (or pulmonary artery wedge) pressures suggesting a primary or reflex depression of atrial or ventricular function.
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