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  • Title: Exocrine pancreatic function as determined in a same-day test with use of bentiromide and p-aminosalicylic acid.
    Author: Berg JD, Chesner IM, Allen-Narker RA, Buckley BM, Lawson N.
    Journal: Clin Chem; 1986 Jun; 32(6):1010-2. PubMed ID: 3486726.
    Abstract:
    We describe a new approach to the bentiromide test of exocrine pancreatic function, p-Aminosalicylic acid (PAS), a compound closely related to the bentiromide fragment p-aminobenzoic acid (PABA), is used as a marker of the pharmacokinetic behavior of PABA to derive a PABA excretion index. This index is identical to that derived with [14C]-PABA. Concentrations of both PABA and PAS are measured in urine by "high-performance" liquid chromatography, which avoids the drug interferences encountered with established assays of PABA. We discuss the practical and diagnostic advantages of this new approach to the bentiromide test.
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