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  • Title: Penetration of amoxycillin and clavulanic acid into bone.
    Author: Grimer RJ, Karpinski MR, Andrews JM, Wise R.
    Journal: Chemotherapy; 1986; 32(3):185-91. PubMed ID: 3486754.
    Abstract:
    The levels of amoxycillin and clavulanic acid have been measured in bone, serum and synovial fluid following the administration of 1.2 g Augmentin prior to hip replacement. Both antibiotics readily enter synovial fluid in levels similar to that found in serum. The levels found in bone are a minimum of ten times lower than those found in serum. Sequential administration of Augmentin with a six-hourly dose schedule does not increase the levels found in any of the tissues studied.
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