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  • Title: Effects of bepridil and of its quaternary derivative on rat tail artery.
    Author: Schaeffer P, Baissat J, Dureng G, Lamar JC, Stoclet JC.
    Journal: Eur J Pharmacol; 1986 Apr 09; 123(1):155-9. PubMed ID: 3486771.
    Abstract:
    The effects of bepridil and its quaternary ammonium derivative (BN+) were compared, showing that: (i) both drugs inhibited K+-induced contractions with similar time courses and potencies, (ii) bepridil blocked the tonic but not the phasic component of contractions elicited by noradrenaline, whereas BN+ had no effect on noradrenaline-elicited contractions. These results, and the relative insensitivity of skinned taenia caeci to bepridil, suggest that this drug and BN+ do not act directly on contractile proteins but affect K+- and noradrenaline-induced calcium channel activities differentially.
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