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  • Title: Radiation-induced alterations in binding of concanavalin A to cells and in their susceptibility to agglutination.
    Author: Takahashi K, Kaneko I.
    Journal: Int J Radiat Biol Relat Stud Phys Chem Med; 1986 Jun; 49(6):979-86. PubMed ID: 3486853.
    Abstract:
    Cell susceptibility to agglutination mediated by a plant lectin, concanavalin A (Con A), and the binding capacity of Con A to cells following gamma-irradiation have been examined in mouse myeloid leukaemia cells cultured in suspension. Irradiation caused an immediate decrease in the amount of Con A bound to the cell surface, whereas susceptibility of irradiated cells to agglutination by Con A was unchanged when compared to that of the unirradiated cells. Post-irradiation incubation of cells at 37 degrees C resulted in a temporary, more than 1.3-fold increase in cell susceptibility to agglutination 60 min after irradiation, whereas binding capacity of cells for Con A gradually recovered following irradiation, reaching a comparable level to that of unirradiated cells 3 h after irradiation. Cell susceptibility to agglutination by Con A does not depend strongly on its binding capacity.
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