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  • Title: The production of prostaglandin and the regulation of cell division in neonate rat primary mixed glial cultures.
    Author: DuBois JH, Bolton C, Cuzner ML.
    Journal: J Neuroimmunol; 1986 Jun; 11(4):277-85. PubMed ID: 3486884.
    Abstract:
    The production of prostaglandins has been studied in neonate rat primary mixed glial cultures. A correlation was found between inhibition of [3H]thymidine incorporation in the cultures and production of prostaglandin, which was stimulated by the addition of supernatant from Con A-activated rat splenocytes. Inhibition of prostaglandin synthesis in the cultures by indomethacin results in a striking increase in incorporation of [3H]thymidine into the cultures, an effect which was reversed by the addition of exogenous PGE2, but not PGF2 alpha. PGE was the principal prostaglandin detected, with both macrophages/microglia and astrocytes contributing to the output. A possible role for prostaglandins in the modulation of inflammatory responses in the central nervous system is discussed.
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