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  • Title: The influence of immune status on the in vitro sensitivity of serotoninergic receptors in the rat stomach strip.
    Author: Kadlec O, Masek K, Zídek Z.
    Journal: Methods Find Exp Clin Pharmacol; 1986 Feb; 8(2):127-9. PubMed ID: 3487012.
    Abstract:
    Serotoninergic contractions of the rat stomach strip were evoked and EC50 determined. In preparations from control animals MDP, 50 mumol/l, decreased EC50 or sensitized the preparation. In the strips from animals where adjuvant arthritis was induced, higher sensitivity to 5-HT was observed and the sensitizing effect of MDP was retained. In the strips from animals pretreated with cyclophosphamide or in the terminal stage of tumor growth lower sensitivity to 5-HT, which could be further decreased by MDP, were noticed. These opposite effects in serotoninergic reactions were tentatively linked with the modulation of the immune status in vivo.
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