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  • Title: Synthesis and Cytotoxicity of Diarylpentanoids against Sensitive CCRF-CEM and Multidrug-Resistant CEM/ADR5000 Leukemia Cells.
    Author: Di Chio C, Zhou M, Efferth T, Schirmeister T, Zappalà M, Ettari R.
    Journal: Chem Biodivers; 2022 Feb; 19(2):e202100451. PubMed ID: 34871465.
    Abstract:
    This article described the synthesis and biological investigation of a series of symmetric diarylpentanoids, characterized by a dienone moiety and by a different pattern of substitution on the two phenyl rings. The series of compounds 1a-p were tested against drug-sensitive CCRF-CEM and multidrug-resistant CEM/ADR5000 cells to evaluate their cytotoxic profile, and all the diarypentanoids revealed to be active against both the leukemia cell lines, with the best activity shown by compound 1o that showed a submicromolar activity against both CCRF-CEM and CEM/ADR5000 cell lines (EC50 =0.54 and 0.25 μM, respectively).
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