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  • Title: Brain ischemia and infarction positively visualized by pyruvate-1-11C using positron-emission tomography.
    Author: Hara T, Yokoi F, Iio M.
    Journal: Eur J Nucl Med; 1986; 12(1):21-6. PubMed ID: 3488218.
    Abstract:
    We describe positron-emission tomography (PET) scintigraphic findings obtained using pyruvate-1-11C in eight patients with cerebral ischemic hypoxia or infarction. The extraction of 11C by brain tissue from blood after an i.v. injection of 11C-pyruvate was very rapid, being almost complete after a single circulatory passage. Most ischemic lesions were found to be more or less deficient with regard to 11C-extraction capacity. With time, however, the ratio of 11C in ischemic tissue to that in normal tissue was inverted, and the ischemic lesion appeared as a 'hot' area in the scintigram. Very old infarcts did not exhibit this phenomenon. These observations indicate the usefulness of an 11C-pyruvate PET scan for the diagnosis of therapeutically restorable brain damage.
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