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  • Title: Responses of intraepithelial lymphocytes to T-cell mitogens: a comparison between murine and porcine responses.
    Author: Wilson AD, Stokes CR, Bourne FJ.
    Journal: Immunology; 1986 Aug; 58(4):621-5. PubMed ID: 3488265.
    Abstract:
    Intraepithelial lymphocytes (IEL) were isolated from the small intestine of pigs. They showed a strong blastogenic response to the T-cell mitogens phytohaemagglutinin A (PHA), concanavalin A (Con A) and pokeweed mitogen (PWM); in contrast, mouse IEL responded weakly to these mitogens. The response of pig IEL was age-dependent, reaching adult levels by 9 weeks of age. Early weaning of pigs delayed the onset of this response. The effects of inflammatory mediators on the response of mouse IEL were also examined.
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